Titre : 

MCMC Methods for Parameter Estimation in ODE Systems for CAR-T Cell Cancer Therapy$

Résumé : 

In this seminar, we will present a project developed in collaboration with Johnson & Johnson in Basel, focusing on a real clinical case of CAR-T cell cancer therapy. We will show how mathematical modeling and Bayesian statistics can be applied to describe the dynamics of CAR-T cells in the human body. Using systems of ordinary differential equations (ODEs) combined with advanced Markov Chain Monte Carlo (MCMC) and Differential Evolution (DE) algorithms, we estimated key biological parameters from real patient data. The model was implemented and validated in Python, providing a quantitative framework to better understand treatment response and variability. Overall, this work demonstrates how mathematical algorithms can support medical innovation and decision-making in real-world healthcare applications.

Un petit apéritif suivra le séminaire.   ¦     A small aperitif will follow the seminar.

Nous vous attendons nombreux !      ¦     We look forward to seeing many of you there!