Laboratory for bioanalytical chemistry

NematodesNematode tracks on a film of E. coli

The laboratory of bioanalytical chemistry develops novel analytical techniques to decipher the ecology and evolution of small molecule signaling and secondary metabolism in nematodes (roundworms).


"In short, if all the matter in the universe except the nematodes were swept away, our world would still be dimly recognizable, and if, as disembodied spirits, we could then investigate it, we should find its mountains, hills, vales, rivers, lakes, and oceans represented by a film of nematodes. The location of towns would be decipherable, since for every massing of human beings there would be a corresponding massing of certain nematodes. Trees would still stand in ghostly rows representing our streets and highways. The location of the various plants and animals would still be decipherable, and, had we sufficient knowledge, in many cases even their species could be determined by an examination of their erstwhile nematode parasites." (Nathan Augustus Cobb, 1915).


Latest Lab News

Our manuscript describing comparative ascaroside profiling of various Caenorhabditis species and the characterization of species-specific (ω) and (ω – 2)-hydroxylation of ascaroside aglycones downstream of the peroxisomal β-oxidation cycle has been published in a special issue of the Journal of Organic Chemistry (JOC) dedicated to the synthesis of antibiotics and related molecules. The research was performed in collaboration with Prof. Jagan Srinivasan and Douglas K. Reilly from Worcester Polytechnic Institute (WPI), Massachusetts, USA.