Peer-reviewed publications


rac-(2R*,3R*)-S-ethyl 4-chloro-3-hydroxy-2-phenylbutanethioate and rac-(2R*,3R*)-S-ethyl 2-phenyl-3-(tosyloxy)butanethioate: The dichotomy of the stereoselectivity of the Mukaiyama reaction
Olivier Vallat, Ana-Maria Buciumas, Reinhard Neier and Helen Stoeckli-Evans
J. Chem. Cryst 2010, 40, 10-14.


Macrocyclisation of 2-(5-(2-Hydroxyethyl)furan-2-yl)acetic acid Model Compounds of Nonactic Acid
Carine Eng, Jean-Mary Simone, Akane Hartenbach, François Loiseau, Reinhard Neier
Monatshefte für Chemie 2009, 140(3), 349-354.

rac Methyl 4-azido-3-hydroxy-3-(2-nitrophenyl)butanoate
Olivier Vallat, Ana-Maria Buciumas, Reinhard Neier and Helen Stoeckli-Evans
Acta Cryst. E: Structure Reports Online 2009, E65(2), o396-o397.

5-Hydroxyalkyl Derivatives of tert-Butyl 2-oxo-2,5-dihydro-1H-pyrrole-1-caboxylate
Olivier Vallat, Ana-Maria Buciumas, Reinhard Neier and Helen Stoeckli-Evans
Acta Cryst. C : Crystal Structure Communications 2009, C65(4), o171-o175.

Synthesis, structure, and complexation properties of partially and completely reduced meso-octamethylporphyrinogens (calix[4]pyrroles).
Valeria Blangy, Christophe Heiss, Vsevolod Khlebnikov, Christophe Letondor, Helen Stoeckli-Evans
and Reinhard Neier
Angewandte Chemie, International Edition 2009, 48(9), 1688-1691.


Facile Synthesis of a "Ready to Use" Precursor of Porphobilinogen and Its Amino Acid Derivatives
Carole Pissot Soldermann, Ramakrishnan Vallinayagam, Manuel Tzouros, Reinhard Neier
J. Org. Chem 2008, 73, 764-767. .

Glycoside Esters of 5-Aminolevulinic Acid for Photodynamic Therapy of Cancer
Ramakrishnan Vallinayagam, Frederic Schmitt, Jerome Barge, Georges Wagnieres, Virginie Wenger, Reinhard Neier, Lucienne Juillerat-Jeanneret
Bioconjugate Chemistry (2008), 19(4), 821-839.

Novel Bioconjugates of Aminolevulinic Acid with Vitamins
Ramakrishnan Vallinayagam, Joanne Weber, Reinhard Neier
Organic Letters 2008, 10(20), 4453-4455.

Novel Bioconjugates of Aminolevulinic Acid with Nucleosides
Patrice Gurba, Ramakrishnan Vallinayagam, Frédéric Schmitt, Julien Furrer, Lucienne Juillerat-Jeanneret, Reinhard Neier
Synthesis 2008, (24), 3957-3962.


Radical Couplings as Key Steps for the Preparation of Derivatives of Nonactic Acid.
Francois Loiseau, Jean-Mary Simone, David Carcache, Pavel Bobal, Reinhard Neier
Monatshefte fuer Chemie 2007, 138(2), 121-129.

Malonylation/Decarbalkoxylation of Furan Derivatives as Key Steps for the Preparation of Nonactic Acid Derivatives. Part I [1].
Jean-Mary Simone, Francois Loiseau, David Carcache, Pavel Bobal, Julie Jeanneret-Gris, Reinhard Neier
Monatshefte fuer Chemie 2007, 138(2), 131-139.

Malonylation/Decarbalkoxylation of Furan Derivatives as Key Steps for the Preparation of Nonactic Acid Derivatives. Part II [1].
Jean-Mary Simone, Francois Loiseau, David Carcache, Pavel Bobal, Julie Jeanneret-Gris, Reinhard Neier
Monatshefte fuer Chemie 2007, 138(2), 141-147.

Synthesis of bisubstrate inhibitors of porphobilinogen synthase from Pseudomonas aeruginosa.
Sabine Gacond, Frederic Frere, Merle Nentwich, Jean-Philippe Faurite, Nicole Frankenberg-Dinkel, Reinhard Neier
Chemistry & Biodiversity 2007, 4(2), 189-202.

The High Stereoselectivity of the Tandem Sequence Diels-Alder Reaction/Ireland-Claisen Rearrangement Starting from Substituted O-(E)-Buta-1,3-dienyl Ketene Acetals and Cyclic Dienophiles
Nicolas Soldermann, Jörg Velker, Antonia Neels, Helen Stoeckli-Evans, Reinhard Neier
Synthesis 2007, 2379-2387.

Synthesis of Novel and Stable 5-Aminolevulinic Acid Derivatives fort he Efficient Synthesis of 5-Aminolevulinic Acid Based Prodrugs
Ramakrishnan Vallinayagam, Hugo Bertschy, Yann Berger, Virginie Wenger, Reinhard Neier
Synthesis 2007, 3731-3735.


Synthesis of Substituted 1-Thiocyanatobutadienes and their Application in a Diels-Alder/[3,3]Sigmatropic Rearrangement Tandem Reaction
Sebastien Lanaspeze; Reinhard Neier
Monatshefte fuer Chemie 2005, 136(4), 597-607

Determination of Intracellular Prolyl/Glycyl Proteases in Intact Living Human Cells and Protoporphyrin IX Production as a Reporter System
Yann Berger; Catherine Chapuis Bernasconi; Frederic Schmitt; Reinhard Neier; Lucienne Juillerat-Jeanneret
Chemistry & Biology (Cambridge, MA, United States) 2005, 12(8), 867-872.

Structure of yeast 5-aminolaevulinic acid dehydratase complexed with the inhibitor 5-hydroxylaevulinic acid
P.T. Erskine; L. Coates; R. Newbold; A.A. Brindley; F. Stauffer; G.D.E. Beaven; R. Gill; A. Coker; S.P. Wood; M.J. Warren; P.M. Shoolingin-Jordan; R. Neier, J.B. Cooper
Acta Crystallographica, Section D: Biological Crystallography 2005, 61(9), 1222-1226.


Origins of Boat or Chair Preferences in the Ireland-Claisen Rearrangements of Cyclohexenyl Esters: A. Theoretical Study
Khaledy, Mahmood M.; Kalani, Mohammad Y.S., Khuong, Kelli S.; Houk, K.N.; Aviyente Viktorya; Neier, Reinard; Soldermann, Nicolas; Velker, Joerg
Journal of Organic Chemistry 2003, 68(2), 572-577.

An efficient synthesis of 10-substituted benzo[b]phenantro[9,10-d]furans
L. Cires; V. Botomei; I. Humelnicu; H. Ofenberg; R. Neier
Revue Roumaine de Chimie 2003, 48, 33-37.

Evaluation of dipeptide-derivatives of 5-aminolevulinic acid as precursors for phtosensitizers in photodynamic therapy
Yann Berger; Laurent Ingrassia; Reinhard Neier; Lucienne Juillerat-Jeanneret
Bioorganic & Medicinal Chemistry 2003, 11, 1343-1351.

The synthesis of a pyrazol analogon of porphobilinogen with the help of the Mukaiyama aldol reaction.
Andre Chaperon, Hugo Bertschy, Anne-Laurennce Franz-Schrumpf; Bertrand Hugelet; Antonia Neels; Helen Stoeckli-Evans; Reinhard Neier
Chimia 2003, 57(10), 601-606.


Species-specific Inhibition of Porphobilinogen Synthase by 4-Oxosebacic Acid
E.K. Jaffee, J. Kervinen, J. Martins, F. Stauffer, R. Neier, A. Wlodawer, A. Zdanov
J. Biol. Chem. 2002, 277, 19792-19799.

Structure of Porphobilinogen Synthase from Pseudomonas aeruginosa in Complex with 5- Fluorolevulinic Acid Suggests a Double Schiff Base Mechanism
F. Frere, W.-D. Schubert, F. Stauffer, N. Frankenberg, R. Neier, D. Jahn, D.W. Heinz
J. Mol. Boil. 2002, 320, 237-247.


A Novel Synthesis of Porphobilinogen: Synthetic and Biosynthetic Studies
R. Neier
J. Heterocyclic Chem. 2000, 37, 487 - 508

Inhibition Studies of Porphobilinogen Synthase from Escherichia coli using Analogues of Postulated Intermediates
C. Jarret, F. Stauffer, M.E. Henz, M. Marty, R.M. Lüönd, J. Bobalova, P. Schürmann, R. Neier
Chemistry & Biology 2000, 7, 185 - 196

Application of the Novel Tandem Process Diels-Alder Reaction/Ireland-Claisen Rearrangement to the Synthesis of rac-Juvabione and rac-Epijuvabione
N. Soldermann, J. Velker, O. Vallat, H. Stoeckli-Evans, R. Neier
Helv. Chim. Acta 2000, 83, 2266 - 2276.

Aza-Claisen Rearrangements and Diels-Alder Reactions of N,O-Ketene Acetals: Reactivity Studies on the Way to a Novel Tandem-Process
K. Neuschütz, J.-M. Simone, T. Thyrann, R. Neier
Helv. Chim. Acta 2000, 83, 2712 - 2737.

Synthesis of Tri- and Tetrasubstituted Furans Catalyzed by Trifluoroacetic Acid
F. Stauffer, R. Neier
Organic Letters 2000, 2, 3535 - 3537.

Ethylene Glycol and Amino Acid Derivatives of 5-Aminolevulinic Acid as new Photosensitizing Precursors of Protoporphyrin IX in Cells
Y. Berger, A. Greppi, O. Siri, R. Neier, L. Juillerat-Jeanneret
J. Med. Chem. 2000, 43, 4738 - 4746.


A Biomimetic Synthesis of a Porphobilinogen Precursor Using a Mukaiyama Aldol Reaction
A. Chaperon, T.M. Engeloch, R.Neier
Angew. Chem. Int. Ed. 1998, 37, 358, Angew. Chem. 1998, 110, 369

Influence of the nature and substitution of chiral 2,3-epoxy alcohol derivatives on the enantiomeric elution order on Chiracel OD column
C. Zedde, K. Nacro, J.-M. Escudier, M. Baltas, L. Gorrichon, R. Neier
Chirality, 1998, 10, 804-807


Assessment of the Active-Site Requirements of 5-Aminolaevulinic Acid Dehydratase: Evaluation of Substrate and Product Analogues as Competitive Inhibitors
R. M. Lüönd, J. Walker, R. Neier
J. Org. Chem. 1992, 57, 5005


The Photochemical [2 + 2] Cycloaddition to N-Methoxycarbonyl-5,6-dihydro-4-pyridone
P. Guerry, R. Neier
J.C.S. Chem. Commun. 1989, 1727

Variation of [2 + 2]- and [4 + 2]-cycloadditions
R. Neier
Multiprint 1989


Unimolecular Dissociations of Excited C3H6O+
R. Bombach, J. Dannacher, E. Honegger, J.-P. Stadelmann and R. Neier
Chem. Phys. 82, 459 (1983)

Fundamental Aspects of Ionic Dissociations: The Fragmentation Pathways of Excited Bicyclobutane Cations
R. Bombach, J. Dannacher, J.-P. Stadelmann and R. Neier
Helv. 66, 707 (1983)


Biosynthesis of Vitamin B12: Structure of Trimethylisobacteriochlorin from Propionibacterium shermanii
A.R. Battersby, G.W.J. Matcham, E. McDonald, R. Neier, M. Thompson, W.-D. Woggon, V.Y. Bykovsky and H.R. Morris
J.C.S. Chem. Comm. 1979, 185

Biosynthesis of Vitamin B12: Experiments on Loss of C-20 from the Precursur Macrocycle
N.G. Lewis, R. Neier, G.W.J. Matcham, E. McDonald and A.R. Battersby
J.C.S. Chem. Comm. 1979, 541

Biosynthesis of Vitamin B12: Isolation and Proof of Structure of 3-Episirohydrochlorin
A.R. Battersby, E. McDonald, R. Neier and M. Thompson
J.C.S. Chem. Comm. 1979, 960


On the mechanism of the photochemical A/D-secocorrin+corrin-cycloisomerisation
R. Neier
Diss. ETH 6178 (1978)


Photochemical and non-photochemical A/D-secocorrin+corrin-cyclisation
A. Pfaltz, N. Bühler, R. Neier, K. Hirai und A. Eschenmoser
Helv. 60, 2653 (1977)