Fermer

Professor Stephen Clark

Professor Stephen Clark  University of Glasgow, UK

Synthetic organic chemistry and the development of new synthetic methodology and total synthesis of natural products

 

 

 

Clark molecule 2 Clark molecule 1

Literature References

Gambieric Acid A
Isolation and Bioactivity


Nagai, H.; Torigoe, K.; Satake, M.; Murata, M.; Yasumoto, T.; Hirota, H. J. Am. Chem. Soc. 1992, 114, 1102.
Nagai, H.; Murata, M.; Torigoe, K.; Satake, M.; Yasumoto, T. J. Org. Chem. 1992, 57, 5448.
Nagai, H.; Mikami, Y.; Yazawa, K.; Gonoi, T.; Yasumoto, T. J. Antibiot. 1993, 46, 520.
Morohashi, A.; Satake, M.; Nagai, H.; Oshima, Y.; Yasumoto, T. Tetrahedron 2000, 56, 8995.
Inoue, M.; Hirama, M.; Satake, M.; Sugiyama, K.; Yasumoto, T. Toxicon 2003, 41, 469.


Key Synthetic Studies
Kadota, I.; Oguro, N.; Yamamoto, Y. Tetrahedron Lett. 2001, 42, 3645.
Kadota, I.; Takamura, H.; Yamamoto, Y. Tetrahedron Lett. 2001, 42, 3649.
Sato, K.; Sasaki, M. Org. Lett. 2005, 7, 2441.
Roberts, S. W.; Rainier, J. D. Org. Lett. 2007, 9, 2227.
Sato, K.; Sasaki, M. Angew. Chem. Int. Ed. 2007, 46, 2518.
Fuwa, H.; Ishigai, K.; Goto, T.; Suzuki, A.; Sasaki, M. J. Org. Chem. 2009, 74, 4024.
Fuwa, H.; Noji, S.; Sasaki, M. J. Org. Chem. 2010, 75, 5072.


Hemibrevetoxin B

Isolation


Prasad, A. V. K.; Shimizu, Y. J. Am. Chem. Soc. 1989, 111, 6476.


Total Syntheses

Nicolaou, K. C.; Reddy, K. R.; Skokotas, G.; Sato, F.; Xiao, X.-Y. J. Am. Chem. Soc. 1992, 114, 7935.
Kadota, I.; Park, J.-Y.; Koumura, N.; Pollaud, G.; Matsukawa, Y.; Yamamoto, Y. Tetrahedron Lett. 1995, 36, 5777.
Morimoto, M.; Matsukura, H.; Nakata, T. Tetrahedron Lett. 1996, 37, 6365.
Kadota, I.; Yamamoto, Y. J. Org. Chem. 1998, 63, 6597.
Rainier, J. D.; Allwein, S. P.; Cox, J. M. J. Org. Chem. 2001, 66, 1380.
Zakarian, A.; Batch, A.; Holton, R. A. J. Am. Chem. Soc. 2003, 125, 7822.


Ciguatoxin CTX-3C
Isolation and Bioactivity


Yasumoto, T.; Fukui, M.; Sasaki, K.; Sugiyama, K. J. AOAC Int. 1995, 78, 574.
Satake, M.; Fukui, M.; Legrand, A. M.; Cruchet, P.; Yasumoto, T. Tetrahedron Lett. 1998, 39, 1197.


Total Syntheses
Hirama, M.; Oishi, T.; Uehara, H.; Inoue, M.; Maruyama, M.; Oguri, H.; Satake, M. Science 2001, 294, 1904.
Inoue, M.; Uehara, H.; Maruyama, M.; Hirama M. Org. Lett. 2002, 4, 4551.
Inoue, M.; Hirama M. Acc. Chem. Res. 2004, 37, 961.
Inoue, M.; Miyazaki, K.; Uehara, H.; Maruyama, M.; Hirama, M. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 12013.
Hirama, M. Chem. Rec. 2005, 5, 240.
Inoue, M.; Miyazaki, K.; Ishihara, Y.; Tatami, A.; Ohnuma, Y.; Kawada, Y.; Komano, K.; Yamashita, S.; Lee, N.; Hirama M. J. Am. Chem. Soc. 2006, 128, 9352.
Yamashita, S.; Ishihara, Y.; Morita, H.; Uchiyama, J.; Takeuchi, K.; Inoue, M.; Hirama, M. J. Nat. Prod. 2011, 74, 357.


Key Publications from the Clark Reseach Group
 

Clark, J. S. Chem. Commun. 2006, 3571 (Feature Article).
Clark, J. S.; Kettle, J. G. Tetrahedron Lett. 1997, 38, 123.
Clark, J. S.; Kettle, J. G. Tetrahedron Lett. 1997, 38, 127.
Clark, J. S.; Hamelin, O.; Hufton, R. Tetrahedron Lett. 1998, 39, 8321.
Clark, J. S.; Trevitt, G. P.; Boyall, D.; Stammen, B. Chem. Commun. 1998, 2629.
Clark, J. S.; Kettle, J. G. Tetrahedron 1999, 55, 8231.
Clark, J. S.; Hamelin, O. Angew. Chem. Int. Ed. 2000, 39, 372.
Clark, J. S.; Elustondo, F.; Trevitt, G. P.; Boyall, D.; Robertson, J.; Blake, A. J.; Wilson, C.; Stammen, B. Tetrahedron 2002, 58, 1973.
Clark J. S.; Fessard, T. C.; Wilson, C. Org. Lett. 2004, 6, 1773.
Clark, J. S.; Elustondo, F.; Kimber, M. C. Chem. Commun. 2004, 2470.
Clark, J. S.; Kimber, M. C.; Robertson, J.; McErlean, C. S. P.; Wilson, C. Angew. Chem. Int. Ed. 2005, 44, 6157.
Clark, J. S.; Grainger, D. M.; Ehkirch, A. A.-C.; Blake, A. J.; Wilson, C. Org. Lett. 2007, 9, 1033.
Clark, J. S.; Conroy, J.; Blake, A. J. Org. Lett. 2007, 9, 2091.